An analysis of tissue-specific transplantation phenomena in a minor histoincompatibility system.
CJ Simeonovic, PD Hodgkin, JA Donohoe, KM Bowen, KJ Lafferty
Transplantation | Published : 1985
Tissue-specific differences in immunogenicity were demonstrated following allotransplantation across the same minor histocompatibility barrier (BALB/c----DBA/2). In contrast to the high immunogenicity of fetal pancreas and skin, isolated islets, fetal proislets, and thyroid were weakly immunogenic. These tissue-specific effects were not related to the presence of tissue-specific antigens or the absence of recognizable minor alloantigens from the less immunogenic tissues. There was a strong correlation between tissues that were highly immunogenic and those that contained rich populations of donor leukocytes. The survival of fetal pancreas allografts was significantly improved by pretreating t..View full abstract