Journal article

Type 1 diabetes: a disease of developmental origins

Jessica E Phillips, Jennifer J Couper, Megan AS Penno, Leonard C Harrison



The incidence of type 1 diabetes globally has increased dramatically over the last 50 years. Proposed environmental reasons for this increase mirror the modern lifestyle. Type 1 diabetes can be viewed as part of the non- communicable disease epidemic in our modern society. Meanwhile rapidly evolving new technologies are advancing our understanding of how human microbial communities interface with the immune system and metabolism, and how the modern pro-inflammatory environment is changing these communities and contributing to the rapid rise of non-communicable disease. The majority of children who present with clinical type 1 diabetes are of school age; however 80% of children who develop ty..

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Funding Acknowledgements

This research is supported by JDRF Australia, the recipient of the Australian Research Council Special Research Initiative in Type 1 Juvenile Diabetes; The Helmsley Charitable Trust; JDRF International; the National Health and Medical Research Council; Pfizer and Channel 7 Research Foundation.