Structural differences between insulin and somatomedin-C/insulin-like growth factor-1 receptors revealed by autoantibodies to the insulin receptor.
HA Jonas, RC Baxter, LC Harrison
Biochem Biophys Res Commun | Published : 1982
Five sera containing autoantibodies to the insulin receptor were used to compare the immunological characteristics of the insulin and the somatomedin-C/insulin-like growth factor-1 receptors of Triton-solubilized human placental membranes. Complete immunoprecipitation of [125I] insulin-labelled receptors was achieved using all five antisera. Three antisera precipitated 90, 65 and 40% of [125I] insulin-like growth factor-1-labelled receptors while the other two caused less than 7% immunoprecipitation. These results are consistent with the view that insulin and insulin-like growth factor-1 receptors are separate molecules which although structurally similar, possess a significant degree of imm..View full abstract