Decreased binding of insulin by receptors on placental membranes from diabetic mothers.
LC Harrison, T Billington, S Clark, R Nichols, I East, FI Martin
The Journal of Clinical Endocrinology & Metabolism | Published : 1977
Specific binding of insulin to microsomal membranes from the placentae of insulin-dependent diabetics was significantly decreased when compared with normals. This was due to an apparent decrease in the concentration of insulin receptors.