Journal article

Impairment of insulin secretion during experimental potassium depletion is not corrected by the prostaglandin synthesis inhibitor, indomethacin.

R Düsing, LC Harrison, S Bhathena, L Recant, FC Bartter

Clin Endocrinol (Oxf) | Published : 1981

Abstract

The effect of potassium depletion on glucose tolerance, plasma insulin and plasma glucagon was studied in six normal young female subjects. Negative potassium balance was induced by a diet low in potassium, together with frusemide (40 mg/day), for 3 days. Studies were performed during a period of potassium depletion and were repeated during potassium depletion in five subjects taking indomethacin (150 mg/day), an inhibitor of prostaglandin biosynthesis. Mean plasma potassium concentration was reduced from 4·2 ± 0·1 mmol/l to 3·3 ± 0·1 mmol/l, and was 3·2 ± 0·1 mmol/l during administration of indomethacin. Potassium depletion had no significant effect on the levels of plasma glucose, either f..

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