Effects of angiotensin on plasma electrolyte concentrations in rabbits and in man.
JK Healy, AJ Elliott, LC Harrison
Clin Sci Mol Med | Published : 1974
The effects of an intravenous infusion of angiotensin on plasma electrolytes were examined in normal, adrenalectomized and nephrectomized groups of rabbits and in normal man. Rabbits were given 1 μg kg-1 min-1 and human subjects 0.008-0.030 μg kg-1 min-1 of angiotensin. In normal rabbits, angiotensin increased arterial and venous plasma K within 2 min by 0.8 and 0.4 mmol l-1 respectively, some hyperkalemia persisting for 30-60 min. After 60 min arterial plasma Na decreased by 3.8 mmol l-1 and Cl by 2.4 mmol l-1. Arterial blood pH increased 0.04 units after 15 min, and arterial plasma Mg and Ca rose slightly after 2 min. Pressor response was 20-28 mmHg. In adrenalectomized and nephrectomized ..View full abstract