Journal article

Sources of improvement in between laboratory variation in estrogen and progestin receptor measurement using tissue samples during the Australian Quality Assurance Programme.

BW Borjesson, MN Cauchi, PJ Compton, PA Elder, TM Foo, C Gramacho, R Hähnel, LC Harrison, IM Holdaway, DJ Horsfall

Eur J Cancer Clin Oncol | Published : 1989


Tissue and cytosol samples were compared as quality control material for assessment of between and within laboratory error in measurement of estrogen and progestin receptors (ER and PR) in a series of four trials for a total of 17 participating laboratories during the Australasian Quality Assurance Programme. For tissue samples, a substantial reduction in between laboratory CVs for both ER and PR from about 90 to 50% was achieved during the programme. In contrast, for cytosol samples a substantially lower between laboratory CV of about 30% was obtained. Tissue sample heterogeneity could be excluded as a major source of variation between laboratories. The likely source of the observed improve..

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University of Melbourne Researchers