Heterogeneity of the insulin-receptor interaction in lipoatropic diabetes.
H Wachslicht-Rodbard, M Muggeo, CR Kahn, GA Saviolakis, LC Harrison, JS Flier
J Clin Endocrinol Metab | Published : 1981
 Insulin binding to its receptors was studied on circulating cells from 11 patients (8 females and 3 males) with lipoatropic diabetes. The patients ranged in age from 9-54 yr. All were insulin resistant, as evidenced by fasting hyperinsulinemia and insulin tolerance tests. Nine patients were evaluated by specific  insulin binding to monocytes. Three different patterns of receptor abnormalities were observed: 3 patients demonstrated decreased binding due to decreased binding capacity, 2 patients revealed normal tracer binding with decreased receptor affinity,, and 4 patients had normal or increased insulin binding.  Insulin binding to erythrocytes in 9 cases demonstrated simila..View full abstract