Journal article

Heterogeneity of the insulin-receptor interaction in lipoatropic diabetes.

H Wachslicht-Rodbard, M Muggeo, CR Kahn, GA Saviolakis, LC Harrison, JS Flier

J Clin Endocrinol Metab | Published : 1981


[125] Insulin binding to its receptors was studied on circulating cells from 11 patients (8 females and 3 males) with lipoatropic diabetes. The patients ranged in age from 9-54 yr. All were insulin resistant, as evidenced by fasting hyperinsulinemia and insulin tolerance tests. Nine patients were evaluated by specific [125] insulin binding to monocytes. Three different patterns of receptor abnormalities were observed: 3 patients demonstrated decreased binding due to decreased binding capacity, 2 patients revealed normal tracer binding with decreased receptor affinity,, and 4 patients had normal or increased insulin binding. [125] Insulin binding to erythrocytes in 9 cases demonstrated simila..

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University of Melbourne Researchers