Journal article

Antigen-specific therapy for autoimmune disease.

LC Harrison, DA Hafler

Curr Opin Immunol | Published : 2000

Abstract

The application of self-antigens as therapeutic tools is validated in inbred animal models of autoimmune disease. Mechanisms of antigen-induced tolerance (apoptosis, anergy, regulatory T cells and immune deviation) are being clarified in relation to the properties of antigens and the modes and routes of their delivery. Mucosa-mediated tolerance remains the predominant mode of antigen-specific therapy but awaits demonstration of clinical efficacy in human autoimmune disease.

University of Melbourne Researchers