Journal article

Reappraising the stereotypes of diabetes in the modern diabetogenic environment

John M Wentworth, Spiros Fourlanos, Leonard C Harrison

Nature Reviews Endocrinology | NATURE PUBLISHING GROUP | Published : 2009


The prevailing concentration of blood glucose is a result of the integrated regulation of insulin secretion and insulin action. Nevertheless, the classic stereotypes of diabetes are dichotomous: type 1 diabetes mellitus (T1DM) is attributed to impaired insulin secretion, and type 2 diabetes mellitus (T2DM) is primarily attributed to impaired insulin action (insulin resistance). The available evidence indicates that this view is overly simplistic. Impaired insulin secretion (beta-cell dysfunction) is also a feature of T2DM, and insulin resistance is also a risk factor for the development of T1DM. Moreover, with the increasing incidence of T2DM and T1DM in both developed and developing countri..

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Awarded by National Health and Medical research Council of Australia (NHMRC)

Funding Acknowledgements

This work was funded by Program (516700) and infrastructure (361646) grants from the National Health and Medical research Council of Australia (NHMRC), a victorian state Government Operational infrastructure support Grant, the Diabetes Australia research Trust (DART) and the royal Australian College of Physicians research Foundation. J. M. Wentworth is a Doherty Fellow, and L. C. Harrison is a senior Principal research Fellow, of the NHMRC.