Journal article

Evidence of proteinuria, but no other characteristics of pre-eclampsia, in relaxin-deficient mice

Kelly P O'Sullivan, Sarah A Marshall, Scott Cullen, Tahnee Saunders, Natalie J Hannan, Sevvandi N Senadheera, Laura J Parry



Pre-eclampsia (PE) is a leading cause of maternal and fetal death, characterised by an imbalance of placental growth factors and hypertension at >20 weeks gestation. Impaired maternal systemic vascular adaptations and fetal growth restriction are features of both PE and pregnant relaxin-deficient (Rln-/-) mice. The aim of the present study was to investigate whether these phenotypes in Rln-/- mice are associated with abnormal placental growth factor expression, increased soluble fms-like tyrosine kinase-1 (sFlt-1), proteinuria and/or hypertension during pregnancy. In addition, we examined relaxin and relaxin receptor (relaxin/insulin like family peptide receptor 1 (RXFP1)) mRNA expression in..

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Funding Acknowledgements

This work was supported by an Australian National Health and Medical Research Council Project Grant to LJP and ST. NJH received salary support from The University of Melbourne (CR Roper Fellowship) and SAM received a University of Melbourne Research Scholarship. The authors acknowledge clinical research midwives Gabrielle Pell, Rachel Murdoch and Genevieve Christophers and the Obstetrics midwifery staff and patients at the Mercy Hospital for Women (Heidelberg, Vic., Australia) for provision of placental tissue. The authors also thank Ms Tania Long and Mr Darren Cipolla for assisting with the maintenance of the mouse colony used in the present study.