Journal article

Cell death and thymic tolerance

Stephen R Daley, Charis Teh, Daniel Y Hu, Andreas Strasser, Daniel HD Gray



The differentiation of hematopoietic precursors into the many functionally distinct T-cell types produced by the thymus is a complex process. It proceeds through a series of stages orchestrated by a variety of thymic microenvironments that shape the T-cell developmental processes. Numerous cytokine and cell surface receptors direct thymocyte differentiation but the primary determinant of cell fate is the engagement of the T-cell antigen receptor (TCR). The strength of the TCR signal and the maturation stage of the thymocyte receiving it can direct the various differentiation programs or, alternatively, end the process by inducing cell death. The regulation of thymocyte death is critical for ..

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Awarded by National Health and Medical Research Council

Awarded by NHMRC

Awarded by Leukemia and Lymphoma Society

Awarded by RD Wright Fellowship

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

Biomedicine Discovery Institute, Monash University; National Health and Medical Research Council, Grant/Award Number: 1107464 and 1078763; NHMRC Early Career Fellowship, Grant/Award Number: 1089072; NHMRC Senior Principal Research Fellow (SPRF), Grant/Award Number: 1020363; NHMRC Program Grant, Grant/Award Number: 1113113; Leukemia and Lymphoma Society, Grant/Award Number: 7413 and 7001-13; RD Wright Fellowship, Grant/Award Number: 1090236