Journal article

The spatio-temporal mechanical environment of healthy and injured human cartilage during sustained activity and its role in cartilage damage

Saeed Miramini, David W Smith, Lihai Zhang, Bruce S Gardiner

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS | ELSEVIER SCIENCE BV | Published : 2017

Abstract

Recently we presented a computational model of articular cartilage calibrated for normal human tissue explants. This model was able to capture the transient deformation of cartilage experiencing a cyclic load. The model takes into account the tension-compression nonlinearity of the cartilage and incorporates the dependency of the compressive stiffness and fluid permeability of cartilage on the deformation-dependent aggrecan concentration in cartilage tissue. As such it represents a leading constitutive model of articular cartilage. Here we build on the previous study to develop an experimentally validated computational model to simulate mechanical consolidation response of intact and previou..

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