The spatio-temporal mechanical environment of healthy and injured human cartilage during sustained activity and its role in cartilage damage
Saeed Miramini, David W Smith, Lihai Zhang, Bruce S Gardiner
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS | ELSEVIER SCIENCE BV | Published : 2017
Recently we presented a computational model of articular cartilage calibrated for normal human tissue explants. This model was able to capture the transient deformation of cartilage experiencing a cyclic load. The model takes into account the tension-compression nonlinearity of the cartilage and incorporates the dependency of the compressive stiffness and fluid permeability of cartilage on the deformation-dependent aggrecan concentration in cartilage tissue. As such it represents a leading constitutive model of articular cartilage. Here we build on the previous study to develop an experimentally validated computational model to simulate mechanical consolidation response of intact and previou..View full abstract
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Awarded by Australian Federal Government NH MRC
The authors would like to acknowledge the funding support of this project by the Australian Federal Government NH & MRC APP1051538 grant.