Journal article

B Cell Homeostasis in Chronic Hepatitis C Virus-Related Mixed Cryoglobulinemia Is Maintained Through Naive B Cell Apoptosis

Lauren E Holz, Joo Chun Yoon, Sukanya Raghuraman, Susan Moir, Michael C Sneller, Barbara Rehermann

HEPATOLOGY | WILEY | Published : 2012

Abstract

UNLABELLED: Mixed cryoglobulinemia (MC) is the most common extrahepatic manifestation of chronic hepatitis C virus (HCV) infection. Although the formation of inflammation-triggering immune complexes is driven by clonal expansions of autoreactive B cells, we found total B cell numbers paradoxically reduced in HCV-infected patients with MC. HCV patients with MC (n = 17) also displayed a reduced number and a reduced frequency of naïve B cells compared with HCV-infected patients without MC (n = 19), hepatitis B virus-infected patients (n = 10), and uninfected controls (n = 50). This was due to an increased sensitivity of naïve B cells to apoptosis resulting in a reduction in the size of the naïv..

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University of Melbourne Researchers