B Cell Homeostasis in Chronic Hepatitis C Virus-Related Mixed Cryoglobulinemia Is Maintained Through Naive B Cell Apoptosis
Lauren E Holz, Joo Chun Yoon, Sukanya Raghuraman, Susan Moir, Michael C Sneller, Barbara Rehermann
HEPATOLOGY | WILEY | Published : 2012
UNLABELLED: Mixed cryoglobulinemia (MC) is the most common extrahepatic manifestation of chronic hepatitis C virus (HCV) infection. Although the formation of inflammation-triggering immune complexes is driven by clonal expansions of autoreactive B cells, we found total B cell numbers paradoxically reduced in HCV-infected patients with MC. HCV patients with MC (n = 17) also displayed a reduced number and a reduced frequency of naïve B cells compared with HCV-infected patients without MC (n = 19), hepatitis B virus-infected patients (n = 10), and uninfected controls (n = 50). This was due to an increased sensitivity of naïve B cells to apoptosis resulting in a reduction in the size of the naïv..View full abstract
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
Supported by the National Institutes of Health intramural research program (National Institute of Diabetes and Digestive and Kidney Diseases and National Institute of Allergy and Infectious Diseases).