Journal article

Early intrahepatic antigen-specific retention of naive CD8( ) T cells is predominantly ICAM-1/LFA-1 dependent in mice

P Bertolino, A Schrage, DG Bowen, K Klugewitz, S Ghani, K Eulenburg, L Holz, N Hogg, GW McCaughan, A Hamann

HEPATOLOGY | WILEY | Published : 2005

Abstract

We have previously shown that naïve CD8+ T cells recognizing their cognate antigen within the liver are retained and undergo activation in situ, independent from lymphoid tissues. Intrahepatic primary T cell activation results in apoptosis and may play a crucial role in the ability of the liver to induce tolerance. Although adhesion molecules required for intrahepatic retention of T cells that have undergone previous extra-hepatic activation have been characterized, adhesive interactions involved in selective antigen-dependent intrahepatic retention of naïve CD8+ T cells have not been investigated. By adoptively transferring radiolabeled T cell receptor (TCR)-transgenic CD8+ T cells into rec..

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