Journal article

Invading macrophages play a major role in the liver progenitor cell response to chronic liver injury

Cornelia S Viebahn, Volker Benseler, Lauren E Holz, Caryn L Elsegood, Michelle Vo, Patrick Bertolino, Ruth Ganss, George CT Yeoh

JOURNAL OF HEPATOLOGY | ELSEVIER SCIENCE BV | Published : 2010

Abstract

BACKGROUND & AIMS: Although a strong association between liver progenitor cells (LPCs) and inflammation exists in many chronic liver diseases, the exact role of the immune system in LPC-mediated hepatic regeneration remains unclear. A number of pro-inflammatory factors were identified in cytokine knockout mice in which the LPC response was attenuated but neither the mechanism nor the producing cells are known. METHODS: To identify the critical immune cells and cytokines required in the LPC response, we compared two diet-induced models of liver injury with two recently established transgenic models of immune-mediated hepatitis. RESULTS: Despite severe inflammation being observed in all models..

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University of Melbourne Researchers