Journal article
Invading macrophages play a major role in the liver progenitor cell response to chronic liver injury
Cornelia S Viebahn, Volker Benseler, Lauren E Holz, Caryn L Elsegood, Michelle Vo, Patrick Bertolino, Ruth Ganss, George CT Yeoh
JOURNAL OF HEPATOLOGY | ELSEVIER SCIENCE BV | Published : 2010
Abstract
BACKGROUND & AIMS: Although a strong association between liver progenitor cells (LPCs) and inflammation exists in many chronic liver diseases, the exact role of the immune system in LPC-mediated hepatic regeneration remains unclear. A number of pro-inflammatory factors were identified in cytokine knockout mice in which the LPC response was attenuated but neither the mechanism nor the producing cells are known. METHODS: To identify the critical immune cells and cytokines required in the LPC response, we compared two diet-induced models of liver injury with two recently established transgenic models of immune-mediated hepatitis. RESULTS: Despite severe inflammation being observed in all models..
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Funding Acknowledgements
Funding was provided by the National Health and Medical Research Council and the Cancer Council of Western Australia. C.V. was an IPRS award recipient. We thank Menno van Lookeren Campagne (Genentech Inc., CA, USA) for providing the CRIg antibody, Craig Noble (Olympus, NSW, Australia) for developing the cell counting macros, Kathy Heel (CMCA, WA) for technical support in FACS and Andy Cheng and Alexander Percival for technical assistance.