Journal article

CD8 T cell tolerance following antigen recognition on hepatocytes

Lauren E Holz, Alessandra Warren, David G Le Couteur, David G Bowen, Patrick Bertolino

JOURNAL OF AUTOIMMUNITY | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2010

Abstract

Hepatocytes, the predominant cell type in the liver, are the main cell infected by the hepatitis C virus (HCV) and represent important targets for immune therapy. Although early studies suggested that this parenchymal cell expresses low levels of class I MHC molecules, hepatocytes are emerging as important players in intrahepatic immune responses. Not only do they express high levels of molecules important in antigen presentation, but their expression of these molecules in vivo is also polarized towards the lumen of the sinusoids, thus maximising the efficiency of T cell activation. Electron micrographs indicate that interactions between T cells and hepatocytes occur in vivo via fenestration..

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University of Melbourne Researchers