Early Changes in Natural Killer Cell Function Indicate Virologic Response to Interferon Therapy for Hepatitis C
Golo Ahlenstiel, Birgit Edlich, Leah J Hogdal, Yaron Rotman, Mazen Noureddin, Jordan J Feld, Lauren E Holz, Rachel H Titerence, T Jake Liang, Barbara Rehermann
Gastroenterology | W B SAUNDERS CO-ELSEVIER INC | Published : 2011
BACKGROUND & AIMS: Mathematical modeling of hepatitis C virus (HCV) kinetics indicated that cellular immune responses contribute to interferon (IFN)-induced clearance of HCV. We investigated a potential role of natural killer (NK) cells in this process. METHODS: Phenotype and function of blood and liver NK cells were studied during the first 12 weeks of treatment with pegylated IFN-alfa and ribavirin, the time period used to define the early virological response. RESULTS: Within hours of treatment initiation, NK cells of patients that had an early virological response increased expression of activating receptors NKG2D, NKp30, and CD16 and decreased expression of NKG2C and 2B4, along with inh..View full abstract
Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
This study was supported by the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health intramural research program.