Hepatocyte entry leads to degradation of autoreactive CD8 T cells
Volker Benseler, Alessandra Warren, Michelle Vo, Lauren E Holz, Szun S Tay, David G Le Couteur, Eamon Breen, Anthony C Allison, Nico van Rooijen, Claire McGuffog, Hans J Schlitt, David G Bowen, Geoffrey W McCaughan, Patrick Bertolino
Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2011
Awarded by National Health and Medical Research Council of Australia
Awarded by Deutsche Forschungsgemeinschaft
We thank the Centenary Institute animal and flow cytometry facilities for their technical support; D. Lovejoy for help in performing the radiolabeling experiments; B. Roediger, R. Whan, and E. Kable for help in confocal imaging; A. Strasser, P. Bouillet, and L. O'Reilly for the Bim<SUP>-/-</SUP> mice and the anti-Bim antibody; M. Vadas and W. Weninger for helpful comments on the manuscript; and A. Demetris for reminding us of the literature on emperipolesis. This work was supported by the National Health and Medical Research Council of Australia (Program Grant 571408) and the Ageing and Alzheimer's Research Foundation. V. B. was supported by a Deutsche Forschungsgemeinschaft Postgraduate Research Scholarship (BE 3256/1-2). P. B. was supported by a National Health and Medical Research Council Senior Research Fellowship.