Journal article

Duration of untreated psychosis: Impact of the definition of treatment onset on its predictive value over three years of treatment

Philippe Golay, Luis Alameda, Philipp Baumann, Julien Elowe, Pierre Progin, Andrea Polari, Philippe Conus

JOURNAL OF PSYCHIATRIC RESEARCH | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2016

Abstract

BACKGROUND: While reduction of DUP (Duration of Untreated Psychosis) is a key goal in early intervention strategies, the predictive value of DUP on outcome has been questioned. We planned this study in order to explore the impact of three different definition of "treatment initiation" on the predictive value of DUP on outcome in an early psychosis sample. METHODS: 221 early psychosis patients aged 18-35 were followed-up prospectively over 36 months. DUP was measured using three definitions for treatment onset: Initiation of antipsychotic medication (DUP1); engagement in a specialized programme (DUP2) and combination of engagement in a specialized programme and adherence to medication (DUP3)...

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Grants

Awarded by Swiss National Science Foundation


Awarded by National Center of Competence in Research (NCCR) "SYNAPSY - The Synaptic Bases of Mental Diseases" from the Swiss National Science Foundation


Funding Acknowledgements

Swiss National Science Foundation (#320030_122419 to P.C.); National Center of Competence in Research (NCCR) "SYNAPSY - The Synaptic Bases of Mental Diseases" from the Swiss National Science Foundation (no. 51AU40_125759 to LA); This study was based on institutional funding. There was no role of the funding sources in the study design, analysis and interpretation of data, writing of the manuscript or decision to submit the manuscript.