Journal article

Genetic Dysregulation of Glutathione Synthesis Predicts Alteration of Plasma Thiol Redox Status in Schizophrenia

Rene Gysin, Rudolf Kraftsik, Olivier Boulat, Pierre Bovet, Philippe Conus, Emily Comte-Krieger, Andrea Polari, Pascal Steullet, Martin Preisig, Tanja Teichmann, Michel Cuenod, Kim Q Do

ANTIOXIDANTS & REDOX SIGNALING | MARY ANN LIEBERT, INC | Published : 2011

Abstract

Genetic studies have shown an association between schizophrenia and a GAG trinucleotide repeat (TNR) polymorphism in the catalytic subunit (GCLC) of the glutamate cysteine ligase (GCL), the key enzyme for glutathione (GSH) synthesis. The present study was aimed at analyzing the influence of a GSH dysregulation of genetic origin on plasma thiols (total cysteine, homocysteine, and cysteine-glycine) and other free amino acid levels as well as fibroblast cultures GSH levels. Plasma thiols levels were also compared between patients and controls. As compared with patients with a low-risk GCLC GAG TNR genotype, patients with a high-risk genotype, having an impaired GSH synthesis, displayed a decrea..

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