Genetic Dysregulation of Glutathione Synthesis Predicts Alteration of Plasma Thiol Redox Status in Schizophrenia
Rene Gysin, Rudolf Kraftsik, Olivier Boulat, Pierre Bovet, Philippe Conus, Emily Comte-Krieger, Andrea Polari, Pascal Steullet, Martin Preisig, Tanja Teichmann, Michel Cuenod, Kim Q Do
ANTIOXIDANTS & REDOX SIGNALING | MARY ANN LIEBERT, INC | Published : 2011
Genetic studies have shown an association between schizophrenia and a GAG trinucleotide repeat (TNR) polymorphism in the catalytic subunit (GCLC) of the glutamate cysteine ligase (GCL), the key enzyme for glutathione (GSH) synthesis. The present study was aimed at analyzing the influence of a GSH dysregulation of genetic origin on plasma thiols (total cysteine, homocysteine, and cysteine-glycine) and other free amino acid levels as well as fibroblast cultures GSH levels. Plasma thiols levels were also compared between patients and controls. As compared with patients with a low-risk GCLC GAG TNR genotype, patients with a high-risk genotype, having an impaired GSH synthesis, displayed a decrea..View full abstract
Awarded by Swiss National Science Foundation
We thank all patients and control subjects for their participation and support. We are very grateful to Helene Moser, Adeline Cottier, and Francisca Huppertz for technical help. This work was supported by the "Loterie Romande'' and the Swiss National Science Foundation (grant 310000-116689).