A Label-Free, Quantitative Fecal Hemoglobin Detection Platform for Colorectal Cancer Screening
Gita V Soraya, Thanh C Nguyen, Chathurika D Abeyrathne, Duc H Huynh, Jianxiong Chan, Phuong D Nguyen, Babak Nasr, Gursharan Chana, Patrick Kwan, Efstratios Skafidas
Biosensors | MDPI | Published : 2017
The early detection of colorectal cancer is vital for disease management and patient survival. Fecal hemoglobin detection is a widely-adopted method for screening and early diagnosis. Fecal Immunochemical Test (FIT) is favored over the older generation chemical based Fecal Occult Blood Test (FOBT) as it does not require dietary or drug restrictions, and is specific to human blood from the lower digestive tract. To date, no quantitative FIT platforms are available for use in the point-of-care setting. Here, we report proof of principle data of a novel low cost quantitative fecal immunochemical-based biosensor platform that may be further developed into a point-of-care test in low-resource set..View full abstract
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Awarded by Australian Research Council
This work was performed in part at the Melbourne Centre for Nanofabrication (MCN) in the Victorian Node of the Australian National Fabrication Facility (ANFF). The authors acknowledge the opportunity to use the e- beam evaporator facility of School of Physics at The University of Melbourne and would like to thank Kumaravelu Ganesan for the cleanroom induction and training. Skafidas thanks the generous support of Sue and Leigh Clifford in establishing the Chair in Neural Engineering. Gita Soraya was supported by the Indonesian Endowment Fund for Education (LPDP). This work was supported in part by the Australian Research Council (DP140101967) and the Royal Melbourne Hospital Neuroscience Foundation.