Journal article
Multiple-breath washout outcomes are sensitive to inflammation and infection in children with cystic fibrosis
KA Ramsey, RE Foong, J Grdosic, A Harper, B Skoric, C Clem, M Davis, L Turkovic, SM Stick, SD Davis, SC Ranganathan, GL Hall
Annals of the American Thoracic Society | AMER THORACIC SOC | Published : 2017
Abstract
Rationale: The lung clearance index is a measure of ventilation distribution derived from the multiple-breath washout technique. The lung clearance index is increased in the presence of lower respiratory tract inflammation and infection in infants with cystic fibrosis; however, the associations during the preschool years are unknown. Objectives: We assessed the ability of the lung clearance index to detect the presence and extent of lower respiratory tract inflammation and infection in preschool children with cystic fibrosis. Methods: Ventilation distribution outcomes were assessed at 82 visits with 58 children with cystic fibrosis and at 38 visits with 31 healthy children aged 3-6 years. Ch..
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Awarded by Cystic Fibrosis Foundation Therapeutics
Funding Acknowledgements
Funding for the Australian Respiratory Early Surveillance Team for Cystic Fibrosis program was obtained from the Cystic Fibrosis Foundation Therapeutics (SLY04A0, STICK09A0, and HALL14A0), the National Health and Medical Research Council of Australia (NHMRC; APP513730, APP1020555, and Centre of Research Excellence 1000896), and the Institute for Respiratory Health (2012 [K.A.R.]), and NHMRC fellowships APP1088389 (K.A.R) and APP125550 (G.L.H.). Additional funding was obtained from the Cystic Fibrosis Foundation Therapeutics (DAVIS08Y2 [S.D.D., C.C.]).