Journal article

In situ handheld three-dimensional bioprinting for cartilage regeneration

Claudia Di Bella, Serena Duchi, Cathal D O'Connell, Romane Blanchard, Cheryl Augustine, Zhilian Yue, Fletcher Thompson, Christopher Richards, Stephen Beirne, Carmine Onofrillo, Sebastien H Bauquier, Stewart D Ryan, Peter Pivonka, Gordon G Wallace, Peter F Choong

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE | WILEY | Published : 2018

Abstract

Articular cartilage injuries experienced at an early age can lead to the development of osteoarthritis later in life. In situ three-dimensional (3D) printing is an exciting and innovative biofabrication technology that enables the surgeon to deliver tissue-engineering techniques at the time and location of need. We have created a hand-held 3D printing device (biopen) that allows the simultaneous coaxial extrusion of bioscaffold and cultured cells directly into the cartilage defect in vivo in a single-session surgery. This pilot study assessed the ability of the biopen to repair a full-thickness chondral defect and the early outcomes in cartilage regeneration, and compared these results with ..

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Grants

Awarded by Australian Research Council


Awarded by Australian Laureate Fellowship


Awarded by Australian Research Council Centre of Excellence Scheme


Funding Acknowledgements

Arthritis Australia, Grant/Award Number: Zimmer Australia Grant; Research Endowment Fund, St Vincent's Hospital; Australian Research Council, Grant/Award Number: CE 140100012; Australian Laureate Fellowship, Grant/Award Number: FL110100196; Australian Research Council Centre of Excellence Scheme, Grant/Award Number: 140100012