Differences in white matter structure between seizure prone (FAST) and seizure resistant (SLOW) rat strains

P Sharma; DK Wright; LA Johnston; KL Powell; ME Wlodek; SR Shultz; TJ O'Brien; KL Gilby

Journal article

Differences in white matter structure between seizure prone (FAST) and seizure resistant (SLOW) rat strains

P Sharma, DK Wright, LA Johnston, KL Powell, ME Wlodek, SR Shultz, TJ O'Brien, KL Gilby

Neurobiology of Disease | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2017

DOI: 10.1016/j.nbd.2017.04.022

Abstract

Alterations in white matter integrity have been well documented in chronic epilepsy and during epileptogenesis. However, the relationship between white matter integrity and a predisposition towards epileptogenesis has been understudied. The FAST rat strain exhibit heightened susceptibility towards kindling epileptogenesis whereas SLOW rats are highly resistant. FAST rats also display behavioral phenotypes reminiscent of those observed in neurodevelopmental disorders that commonly comorbid with epilepsy. In this study, we aim to identify differences in white matter integrity that may contribute to a predisposition towards epileptogenesis and its associated comorbidities in 6 month old FAST (n..

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University of Melbourne Researchers

Leigh Johnston Author

Mary Wlodek Author

Pragati Sharma Author

Grants

Awarded by Royal Melbourne Hospital Neuroscience Foundation

Funding Acknowledgements

This work has been funded by an Early Career Research Grant from the University of Melbourne to Dr. Krista Gilby, and grants from the Royal Melbourne Hospital Neuroscience Foundation and the National Health and Medical Research Council (#1082215) to Professor Terence O'Brien.