Journal article

Self-Assembled Nanoparticles from Phenolic Derivatives for Cancer Therapy

Yunlu Dai, Junling Guo, Ting-Yi Wang, Yi Ju, Andrew J Mitchell, Thomas Bonnard, Jiwei Cui, Joseph J Richardson, Christoph E Hagemeyer, Karen Alt, Frank Caruso

ADVANCED HEALTHCARE MATERIALS | WILEY | Published : 2017

Abstract

Therapeutic nanoparticles hold clinical promise for cancer treatment by avoiding limitations of conventional pharmaceuticals. Herein, a facile and rapid method is introduced to assemble poly(ethylene glycol) (PEG)-modified Pt prodrug nanocomplexes through metal-polyphenol complexation and combined with emulsification, which results in ≈100 nm diameter nanoparticles (PtP NPs) that exhibit high drug loading (0.15 fg Pt per nanoparticle) and low fouling properties. The PtP NPs are characterized for potential use as cancer therapeutics. Mass cytometry is used to quantify uptake of the nanoparticles and the drug concentration in individual cells in vitro. The PtP NPs have long circulation times, ..

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Grants

Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by ARC under Australian Laureate Fellowship


Awarded by Discovery Project schemes


Awarded by National Health and Medical Research Council


Funding Acknowledgements

This research was conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). This work was also supported by the ARC under the Australian Laureate Fellowship (F.C., FL120100030), and Discovery Project (F.C., DP130101846) schemes, and the National Health and Medical Research Council under project grant APP1098867. This work was performed in part at the Materials Characterization and Fabrication Platform (MCFP) at The University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF). Part of this research was conducted at the small-angle X-ray scattering (SAXS)/wide-angle X-ray scattering (WAXS) beamline at the Australian Synchrotron. J.J.R. thanks the OCE funding scheme at CSIRO. The authors acknowledge Danzi Song and Ka Fung (Leo) Noi (Department of Chemical and Biomolecular Engineering, The University of Melbourne, Australia) for helpful discussions on pharmacokinetic studies. The authors also acknowledge A/Prof. Clare Parish (Florey Institute of Neuroscience and Mental Health, Australia) for providing access to the microtome.