Squamous cell carcinoma of the skin and voriconazole therapy in lung transplant recipients: A case series

Abstract

Background: Prolonged voriconazole therapy may be associated with skin squamous cell carcinoma (SCC) in lung transplant (LTx) patients. This is of concern given the frequent use of voriconazole in the LTx setting. The impact of voriconazole therapy on the risk of developing skin SCC in an Australian LTx cohort with additional risk due to high levels of sun exposure remains unclear. Aim: This study described the extent and outcomes of new or recurrent skin SCC among LTx patients receiving voriconazole. Methods: The present retrospective cohort study was undertaken at The Alfred Hospital, Australia. Adult LTx recipients with skin SCC who had received voriconazole between 1 July 2003 and 30 Jun..