Mycobacteria-specific cytokine responses as correlates of treatment response in active and latent tuberculosis

V Clifford; M Tebruegge; C Zufferey; S Germano; B Forbes; L Cosentino; E McBryde; D Eisen; R Robins-Browne; A Street; J Denholm; N Curtis

Journal article

Mycobacteria-specific cytokine responses as correlates of treatment response in active and latent tuberculosis

V Clifford, M Tebruegge, C Zufferey, S Germano, B Forbes, L Cosentino, E McBryde, D Eisen, R Robins-Browne, A Street, J Denholm, N Curtis

Journal of Infection | W B SAUNDERS CO LTD | Published : 2017

DOI: 10.1016/j.jinf.2017.04.011

Abstract

Objectives A biomarker indicating successful tuberculosis (TB) therapy would assist in determining appropriate length of treatment. This study aimed to determine changes in mycobacteria-specific antigen-induced cytokine biomarkers in patients receiving therapy for latent or active TB, to identify biomarkers potentially correlating with treatment success. Methods A total of 33 adults with active TB and 36 with latent TB were followed longitudinally over therapy. Whole blood stimulation assays using mycobacteria-specific antigens (CFP-10, ESAT-6, PPD) were done on samples obtained at 0, 1, 3, 6 and 9 months. Cytokine responses (IFN-γ, IL-1ra, IL-2, IL-10, IL-13, IP-10, MIP-1β, and TNF-α) in su..

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University of Melbourne Researchers

Roy Robins-Browne Author

Justin Denholm Author

Nigel Curtis Author

Vanessa Clifford Author

Grants

Funding Acknowledgements

This study was supported by a grant from the John Burge Trust. Vanessa Clifford was supported by an Australian Government Research Training Scholarship.