Journal article
Antibody responses to plasmodium falciparum and plasmodium vivax and prospective risk of plasmodium spp. Infection postpartum
ARD McLean, M Boel, R McGready, R Ataide, D Drew, T Tsuboi, JG Beeson, F Nosten, JA Simpson, FJI Fowkes
American Journal of Tropical Medicine and Hygiene | AMER SOC TROP MED & HYGIENE | Published : 2017
Abstract
Postpartum women may have an altered susceptibility to Plasmodium falciparum and Plasmodium vivax. The relationship between naturally acquired malarial immunity and susceptibility to malaria postpartum is yet to be determined. IgG levels were measured against P. falciparum and P. vivax antigens from delivery in 201 postpartum and 201 nonpregnant controls over 12 weeks. Associations between time-varying antibody levels and time to first microscopically confirmed species-specific infection were determined by Cox regression. Associations between antibody levels and prospective risk of Plasmodium infection were similar in postpartum and control women. A 2-fold increase in P. falciparum antibody ..
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Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (project grant and training award to Freya J. I. Fowkes; Infrastructure for Research Institutes Support Scheme grant), Australian Research Council (Future Fellowship to Freya J. I. Fowkes), and Victorian State Government Operational Infrastructure Support grant to the Burnet Institute. Alistair R. D. McLean is supported by an Australian Postgraduate Award. Shoklo Malaria Research Unit is part of the Mahidol Oxford University Tropical Medicine Research Unit supported by the Wellcome Trust of Great Britain. The Christophe and Rodolphe Merieux Foundation supported the study through a prize (2008) to Francois Nosten.