Journal article
Mediation of the effect of malaria in pregnancy on stillbirth and neonatal death in an area of low transmission: observational data analysis
Kerryn A Moore, Freya JI Fowkes, Jacher Wiladphaingern, Nan San Wai, Moo Kho Paw, Mupawjay Pimanpanarak, Verena I Carrara, Jathee Raksuansak, Julie A Simpson, Nicholas J White, Francois Nosten, Rose McGready
BMC MEDICINE | BMC | Published : 2017
Abstract
BACKGROUND: Malaria in pregnancy is preventable and contributes significantly to the estimated 5.5 million stillbirths and neonatal deaths that occur annually. The contribution of malaria in pregnancy in areas of low transmission has not been quantified, and the roles of maternal anaemia, small-for-gestational-age status, and preterm birth in mediating the effect of malaria in pregnancy on stillbirth and neonatal death are poorly elucidated. METHODS: We analysed observational data routinely collected at antenatal clinics on the Thai-Myanmar border (1986-2015). We used Cox regression and sequential mediation analysis to determine the effect of falciparum and vivax malaria in pregnancy on ante..
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Awarded by Wellcome Trust of Great Britain (Major Overseas Programme-Thailand Unit Core Grant)
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by Bill & Melinda Gates Foundation
Funding Acknowledgements
The Shoklo Malaria Research Unit is part of the Wellcome Trust Mahidol University Oxford Tropical Medicine Research Programme supported by the Wellcome Trust of Great Britain (Major Overseas Programme-Thailand Unit Core Grant: WT-106698). KAM is supported by an Australian Postgraduate Award funded by the Commonwealth Government of Australia. FJIF is supported by a Future Fellowship funded by the Australian Research Council. KAM and FIJF are supported by an Operational Infrastructure Support grant awarded to the Burnet Institute and funded by the Victorian State Government. JAS is funded by a National Health and Medical Research Council (NHMRC) Senior Research Fellowship (1104975). The data extraction and analysis was supported by a grant funded by the Bill & Melinda Gates Foundation (ID 46589). The funders had no role in analysis design, data collection and analysis, decision to publish, or preparation of the manuscript.