Journal article

Population-based study of grade progression in patients who harboured Gleason 3 3

Fanny Sampurno, Arul Earnest, Jeremy Millar, Mark Frydenberg, Declan Murphy, Warwick Delprado, Sue Evans

World Journal of Urology | SPRINGER | Published : 2017

Abstract

PURPOSE: This study aimed to evaluate (1) the time interval between a decision to commence on active surveillance (AS) and grade progression in community practice; (2) factors predicting grade progression in localised prostate cancer (CaP) patients apparently undergoing AS. METHODS: Data from the Prostate Cancer Outcomes Registry-Victoria were used to analyze men with Gleason 3 + 3 CaP or less who had at least one repeat biopsy. Unadjusted and adjusted 5-year Kaplan-Meier survival curves were used to assess the time to grade progression. Both univariate and multivariate analyses for grade progression were performed using Cox proportional hazards. RESULTS: The cohort included 951 men. Overall..

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