Journal article

Comparison of the efficiency of colorectal cancer screening programs based on age and genetic risk for reduction of colorectal cancer mortality

Oliver Stanesby, Mark Jenkins



Given that colorectal cancer risk depends partly on inherited factors, screening program efficiency may be increased by incorporating genetic factors. We compared the efficiency of screening based on age and genetic risk in a simulated population. We simulated a population matching the size, age distribution and colorectal cancer incidence and mortality of Australia. We also simulated the distribution of genetic risk for colorectal cancer based on the expected number of inherited risk alleles of 45 single-nucleotide polymorphisms (SNPs) previously reported as associated with colorectal cancer. We compared the expected colorectal cancer deaths under three screening programs; age-based, geneti..

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Funding Acknowledgements

MJ is funded by the National Health and Medical Research Council of Australia. The study titles, study leaders and funding sources for data sets used in this manuscript are as follows: 'Quantifying the utility of single-nucleotide polymorphisms to guide colorectal cancer screening', led by MJ; 'Australian cancer incidence and mortality (ACIM) book: Colorectal cancer (also called bowel cancer)', compiled by the Australian Institute of Health and Welfare, with data collection funded by each Australian state or territory through the jurisdictional departments of health (or equivalent) and some non-government organizations. The work of OS on this project was primarily completed as part of his Master's course at the University of Melbourne.