Journal article

Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania

Tom Parks, Mariana M Mirabel, Joseph Kado, Kathryn Auckland, Jaroslaw Nowak, Anna Rautanen, Alexander J Mentzer, Eloi Marijon, Xavier Jouven, Mai Ling Perman, Tuliana Cua, John K Kauwe, John B Allen, Henry Taylor, Kathryn J Robson, Charlotte M Deane, Andrew C Steer, Adrian VS Hill

Nature Communications | NATURE PUBLISHING GROUP | Published : 2017

Grants

Awarded by British Heart Foundation


Awarded by Medical Research Council


Awarded by La Fondation pour la Recherche Medicale


Awarded by Engineering and Physical Sciences Research Council


Awarded by Wellcome Trust Clinical Research Training Fellowship


Awarded by National Health and Medical Research Council of Australia


Awarded by National Heart Foundation of Australia


Awarded by Wellcome Trust


Awarded by National Institute for Health Research


Funding Acknowledgements

This research was supported by grants awarded to T.P. from the British Heart Foundation (PG/14/26/30509), the Medical Research Council (G1100449) and the British Medical Association (Josephine Lansdell Grant 2012). In addition, M.M.M. received funding from La Fondation pour la Recherche Medicale (FDM20140630267), la Federation Francaise de Cardiologie (Bourse d'etudes a l'etranger) and la Fondation Lefoulon Delalande (Bourse post-doctorale); J.N. and C.M.D. received funding from the Engineering and Physical Sciences Research Council (EP/G037280/1); A.J.M. holds a Wellcome Trust Clinical Research Training Fellowship (106289/Z/14/Z); A.C.S. holds a Career Development Fellowship from National Health and Medical Research Council of Australia (1127077) and a Future Leader Fellowship from the National Heart Foundation of Australia (101174); and A.V.S.H. holds Senior Investigator awards from the Wellcome Trust (104750/Z/14/Z) and National Institute for Health Research (NF-SI-0514-10158). None of these funders had any role in study design, data collection and analysis, decision to publish or preparation of the manuscript. We thank the High-Throughput Genomics Group at the Wellcome Trust Centre for Human Genetics for generating the genotyping and sequencing data, subsidized by a core award from the Wellcome Trust (090532/Z/09/Z). We also thank Dr Tara Mills for valuable suggestions regarding the sample collection, Professors Gilean McVean, Jonathan Marchini and Andrew Morris for helpful advice about study design and statistical analysis and Dr Corey Watson for useful discussions concerning the immunoglobulin heavy chain locus. Finally, we thank Professor John Clegg for permission to use the existing Oceanian sample collection and Professors David Weatherall, Don Bowden and their many colleagues for the work involved in establishing that collection.