Physicochemical properties of dietary phytochemicals can predict their passive absorption in the human small intestine
Sophie NB Selby-Pham, Rosalind B Miller, Kate Howell, Frank Dunshea, Louise E Bennett
SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2017
A diet high in phytochemical-rich plant foods is associated with reducing the risk of chronic diseases such as cardiovascular and neurodegenerative diseases, obesity, diabetes and cancer. Oxidative stress and inflammation (OSI) is the common component underlying these chronic diseases. Whilst the positive health effects of phytochemicals and their metabolites have been demonstrated to regulate OSI, the timing and absorption for best effect is not well understood. We developed a model to predict the time to achieve maximal plasma concentration (Tmax) of phytochemicals in fruits and vegetables. We used a training dataset containing 67 dietary phytochemicals from 31 clinical studies to develop ..View full abstract
This project has been funded by Horticulture Innovation Australia Limited using the Vegetable levy and funds from the Australian Government.