Journal article

Reactivity in the human retinal microvasculature measured during acute gas breathing provocations

Angelina Duan, Phillip A Bedggood, Andrew B Metha, Bang V Bui

SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2017

Abstract

Although changes in vessel diameter following gas perturbation have been documented in retinal arterioles and venules, these responses have yet to be quantified in the smallest vessels of the human retina. Here, using in vivo adaptive optics, we imaged 3-25 µm diameter vessels of the human inner retinal circulation and monitored the effects of altered gas-breathing conditions. During isocapnic hyperoxia, definite constrictions were seen in 51% of vessel segments (mean ± SD for pre-capillary arterioles -9.5 ± 3.0%; capillaries -11.8 ± 3.3%; post-capillary venules -6.3 ± 2.8%); these are comparable with responses previously reported in larger vessels. During isoxic hypercapnia, definite dilati..

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Grants

Awarded by Australian Research Council (ARC)


Awarded by ARC


Funding Acknowledgements

This research was supported by: an Australian Research Council (ARC) Discovery Early Career Researcher Award (DE120101931); an ARC Future Fellowship Award (FT130100388); an ARC Discovery Project Grant (DP0984649), an Australian Postgraduate Award from the Australian Government; an A.E. Rowden White Foundation benevolent bequest, and a Melbourne Neuroscience Institute (MNI) Interdisciplinary Seed Fund award from the University of Melbourne.