Journal article

Quantifying sex, race, and age specific differences in bone microstructure requires measurement of anatomically equivalent regionsd

Ali Ghasem-Zadeh, Andrew Burghardt, Xiao-Fang Wang, Sandra Iuliano, Serena Bonaretti, Minh Bui, Roger Zebaze, Ego Seeman

BONE | ELSEVIER SCIENCE INC | Published : 2017

Abstract

INTRODUCTION: Individuals differ in forearm length. As microstructure differs along the radius, we hypothesized that errors may occur when sexual and racial dimorphisms are quantified at a fixed distance from the radio-carpal joint. METHODS: Microstructure was quantified ex vivo in 18 cadaveric radii using high resolution peripheral quantitative computed tomography and in vivo in 158 Asian and Caucasian women and men at a fixed region of interest (ROI), a corrected ROI positioned at 4.5-6% of forearm length and using the fixed ROI adjusted for cross sectional area (CSA), forearm length or height. Secular effects of age were assessed by comparing 38 younger and 33 older women. RESULTS: Ex viv..

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Grants

Awarded by Austin Medical Research Foundation Melbourne, Australia


Awarded by NIH/NIMAS


Awarded by NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES


Funding Acknowledgements

This study was funded by Austin Medical Research Foundation Melbourne, Australia (2-1260) and NIH/NIMAS R01 AR 060700.