Journal article

Differences in Blood Pressure in Infants After General Anesthesia Compared to Awake Regional Anesthesia (GAS Study-A Prospective Randomized Trial)

ME McCann, DE Withington, SJ Arnup, AJ Davidson, N Disma, G Frawley, NS Morton, G Bell, RW Hunt, DC Bellinger, DM Polaner, A Leo, AR Absalom, BS von Ungern-Sternberg, F Izzo, P Szmuk, V Young, SG Soriano, JC de Graaff

ANESTHESIA AND ANALGESIA | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017

Abstract

BACKGROUND: The General Anesthesia compared to Spinal anesthesia (GAS) study is a prospective randomized, controlled, multisite, trial designed to assess the influence of general anesthesia (GA) on neurodevelopment at 5 years of age. A secondary aim obtained from the blood pressure data of the GAS trial is to compare rates of intraoperative hypotension after anesthesia and to identify risk factors for intraoperative hypotension. METHODS: A total of 722 infants ≤60 weeks postmenstrual age undergoing inguinal herniorrhaphy were randomized to either bupivacaine regional anesthesia (RA) or sevoflurane GA. Exclusion criteria included risk factors for adverse neurodevelopmental outcome and infants..

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Grants

Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT


Awarded by National Institute for Health Research


Funding Acknowledgements

All hospitals and centers were generously supported by anesthesiology departmental funding. In addition to this funding, specific grants received for this study are as follows:Australia and New Zealand: The Australian National Health & Medical Research Council, Canberra, Australian Capital Territory, Australia; Australian and New Zealand College of Anaesthetists, Melbourne, Victoria, Australia; Murdoch Children's Research Institute, Melbourne, Victoria, Australia. This study was supported by the Victorian Government's Operational Infrastructure Support Program in Melbourne, Victoria, Australia; Department of Anaesthesia and Pain Management, Royal Children's Hospital, Melbourne, Victoria, Australia; Department of Anaesthesia, Monash Medical Centre, Melbourne, Victoria, Australia; Department of Anaesthesia and Pain Management, Princess Margaret Hospital Foundation, Perth, Western Australia, Australia; Department of Paediatric Anaesthesia, Women's Children's Hospital, Adelaide, South Australia, Australia, and Department of Paediatric Anaesthesia and Operating Rooms, Starship Children's Hospital, Auckland, New Zealand. United States: National Institutes of Health, Bethesda, Maryland; Food and Drug Administration, Silver Spring, Maryland; Department of Anaesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts; Department of Anaesthesia and Pain Medicine, Seattle Children's Hospital, Seattle, Washington; Department of Anaesthesiology, Children's Hospital Colorado, Denver, Colorado; Department of Anaesthesia, University of Iowa Hospital, Iowa City, Iowa; Department of Anaesthesiology, Children's Medical Center Dallas, Texas; Department of Pediatric Anaesthesiology, Anne and Robert H. Lurie Children's Memorial Hospital, Chicago, Illinois; and Department of Anaesthesiology, Dartmouth-Hitchcock Medical Center, Dartmouth, New Hampshire.