Journal article

Associations between systemic bone mineral density and early knee cartilage changes in middle-aged adults without clinical knee disease: a prospective cohort study

Andrew J Teichtahl, Yuanyuan Wang, Anita Wluka, Boyd J Strauss, Joseph Proietto, John B Dixon, Graeme Jones, Flavia M Cicuttini



BACKGROUND: Osteoarthritis has a high prevalence in people with high bone mineral density (BMD). Nevertheless, whether high systemic BMD predates early structural features of knee osteoarthritis is unclear. This study examined the association between systemic BMD and knee cartilage defect progression and cartilage volume loss in middle-aged people without clinical knee disease. METHODS: Adults (n = 153) aged 25-60 years had total body, lumbar spine, and total hip BMD assessed by dual-energy X-ray absorptiometry at baseline (2005-2008), and tibial cartilage volume and tibiofemoral cartilage defects assessed by magnetic resonance imaging at baseline and follow up (2008-2010). RESULTS: Higher s..

View full abstract

University of Melbourne Researchers


Awarded by National Health and Medical Research Council (NHMRC)

Awarded by NHMRC Early Career Fellowship

Awarded by NHMRC

Funding Acknowledgements

This study was supported by the National Health and Medical Research Council (NHMRC) Project Grant 384233, the Shepherd Foundation, and Monash University. The funders had no role in study design, data collection, analysis and interpretation, manuscript preparation, or decision to submit for publication. AJT is the recipient of an NHMRC Early Career Fellowship (#1073284). YW and AEW are the recipients of NHMRC Career Development Fellowship (Clinical Level 1 #1065464 and Clinical Level 2 #1063574, respectively).