Journal article

Defining the Hook Region Anatomy of the Guinea Pig Cochlea for Modeling of Inner Ear Surgery

Jonathon Lo, Phillip Sale, Sudanthi Wijewickrema, Luke Campbell, Hayden Eastwood, Stephen John O'leary

OTOLOGY & NEUROTOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017

Abstract

HYPOTHESIS: The aim of this study was to describe the hook region anatomy of the guinea pig cochlea to identify the optimal surgical approach for cochlear implantation and to determine what anatomical structures are at risk. BACKGROUND: Animal studies investigating hearing loss after cochlear implantation surgery are currently constrained by the lack of a reproducible implantation model. METHODS: Guinea pig cochleae were imaged using thin-sheet laser imaging microscopy. Images were stitched, reconstructed, and segmented for analysis. Insertion vectors were determined by tracing their paths to the outer wall and converting to Cartesian coordinates. Spherical surface and multiplane views were ..

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