Down the rabbit hole: Is necroptosis truly an innate response to infection?
Jaclyn S Pearson, James M Murphy
CELLULAR MICROBIOLOGY | WILEY | Published : 2017
Pathogenic microbes have evolved countless sophisticated mechanisms to subvert host immune responses and cause disease. Understanding evasion strategies employed by pathogens has led to numerous discoveries on specific host cell processes that are critical for controlling infection. Programmed cell death (PCD) is a key host defence to microbial infection, as well as being critical for organ development and cellular homeostasis in multicellular organisms. Much of our current understanding of PCD as a host response to infection has stemmed from the discovery and study of viral inhibitors of apoptosis, and more recently viral inhibition of the newly characterised from of PCD termed necroptosis,..View full abstract
Awarded by National Health and Medical Research Council
Awarded by IRIISS
National Health and Medical Research Council, Grant/Award Number: 1105754, 1057905, 1067289, 1124735, 1124737 and IRIISS 9000220