The Biology of Plasmodium vivax
John H Adams, Ivo Mueller
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT | Published : 2017
Plasmodium vivax is the second most prevalent cause of malaria worldwide and the leading cause of malaria outside of Africa. Although infections are seldom fatal clinical disease can be debilitating and imposes significant health and economic impacts on affected populations. Estimates of transmission and prevalence intensity can be problematic because many episodes of vivax originate from hypnozoite stages in the liver that have remained dormant from previous infections by an unknown mechanism. Lack of treatment options to clear hypnozoites and the ability to infect mosquitoes before disease symptoms present represent major challenges for control and eradication of vivax malaria. Compounding..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by National Institutes of Health
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
I.M. is supported by a National Health and Medical Research Council (NHMRC) Senior Research Fellowship (#1043345) and J.H.A. is supported by the National Institutes of Health (R01 AI064478). The authors thank Ashley Souza for assistance in preparation of this manuscript.