Journal article

Heterogeneity of Purkinje cell simple spike-complex spike interactions: zebrin- and non-zebrin-related variations

Tianyu Tang, Jianqiang Xiao, Colleen Y Suh, Amelia Burroughs, Nadia L Cerminara, Linjia Jia, Sarah P Marshall, Andrew K Wise, Richard Apps, Izumi Sugihara, Eric J Lang

JOURNAL OF PHYSIOLOGY-LONDON | WILEY | Published : 2017

Abstract

KEY POINTS: Cerebellar Purkinje cells (PCs) generate two types of action potentials, simple and complex spikes. Although they are generated by distinct mechanisms, interactions between the two spike types exist. Zebrin staining produces alternating positive and negative stripes of PCs across most of the cerebellar cortex. Thus, here we compared simple spike-complex spike interactions both within and across zebrin populations. Simple spike activity undergoes a complex modulation preceding and following a complex spike. The amplitudes of the pre- and post-complex spike modulation phases were correlated across PCs. On average, the modulation was larger for PCs in zebrin positive regions. Correl..

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University of Melbourne Researchers

Grants

Awarded by National Science Foundation


Awarded by National Institute of Neurological Disorders


Awarded by Japan Society for the Promotion of Science (JSPS)


Awarded by Medical Research Council UK


Awarded by Grants-in-Aid for Scientific Research


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Awarded by Medical Research Council


Funding Acknowledgements

This work was supported by grants to E.J.L. from the National Science Foundation (IOS-1051858) and the National Institute of Neurological Disorders (R21 NS095089); to I.S. from the Japan Society for the Promotion of Science (JSPS) (Grants-in-Aid for Scientific Research-KAKENHI, 16K07025), and to N.L.C. and R.A. from the Medical Research Council UK (G1100626) and Wellcome Trust.