Conference Proceedings
Pharmacological histone deacetylation distinguishes transcriptional regulators
H Rafehi, TC Karagiannis, A El-Osta
Current Topics in Medicinal Chemistry | BENTHAM SCIENCE PUBL LTD | Published : 2017
Abstract
Introduction: Histone deacetylase (HDAC) enzymes control the acetylation status of transcription factors that regulate chromatin structure and gene function. The transcriptional regulatory factors that distinguish histone acetylation and deacetylation patterns by pharmacological HDAC inhibition (HDACi) have not yet been studied. Methods: We analysed sequencing datasets derived from human aortic endothelial cells (HAECs) stimulated with the HDAC inhibitors, Trichostatin A (TSA) and suberoylanilide hydroxamic acid (SAHA). We integrated gene expression and histone acetylation profiles with the transcription factor binding site (TFBS) database derived from the Encyclopedia of DNA Elements (ENCOD..
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Funding Acknowledgements
The authors acknowledge funding support from the Juvenile Diabetes Research Foundation International (JDRF), the National Health and Medical Research Council (NHMRC), and the National Heart Foundation of Australia (NHF). AEO is a Senior Research Fellow supported by the NHMRC. Supported in part by the Victorian Government's Operational Infrastructure Support Program. Epigenomic Medicine Laboratory is supported by an Australian Research Council Future Fellowship and McCord Research (the parental company of Pinnaclife, Inc). This research was supported in part by the Victorian Government's Operational Infrastructure Support Program.