Journal article

Lattice-free descriptions of collective motion with crowding and adhesion.

Stuart T Johnston, Matthew J Simpson, Michael J Plank

Phys Rev E Stat Nonlin Soft Matter Phys | Published : 2013

Abstract

Cell-to-cell adhesion is an important aspect of malignant spreading that is often observed in images from the experimental cell biology literature. Since cell-to-cell adhesion plays an important role in controlling the movement of individual malignant cells, it is likely that cell-to-cell adhesion also influences the spatial spreading of populations of such cells. Therefore, it is important for us to develop biologically realistic simulation tools that can mimic the key features of such collective spreading processes to improve our understanding of how cell-to-cell adhesion influences the spreading of cell populations. Previous models of collective cell spreading with adhesion have used latt..

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University of Melbourne Researchers