Removal of unwanted variation reveals novel patterns of gene expression linked to sleep homeostasis in murine cortex
Jason R Gerstner, John N Koberstein, Adam J Watson, Nikolai Zapero, Davide Risso, Terence P Speed, Marcos G Frank, Lucia Peixoto
BMC GENOMICS | BIOMED CENTRAL LTD | Published : 2016
BACKGROUND: Why we sleep is still one of the most perplexing mysteries in biology. Strong evidence indicates that sleep is necessary for normal brain function and that sleep need is a tightly regulated process. Surprisingly, molecular mechanisms that determine sleep need are incompletely described. Moreover, very little is known about transcriptional changes that specifically accompany the accumulation and discharge of sleep need. Several studies have characterized differential gene expression changes following sleep deprivation. Much less is known, however, about changes in gene expression during the compensatory response to sleep deprivation (i.e. recovery sleep). RESULTS: In this study we..View full abstract
Awarded by National Institute of Mental Health of the National Institutes of Health
Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH
Research reported in this article was supported by the National Institute of Mental Health of the National Institutes of Health under award number R01MH099544 to M.G.F. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The publication charges for this article were funded by start-up funds provided by Washington State University to L.P.