Conference Proceedings

Finding short DNA motifs using permuted Markov models

XY Zhao, HY Huang, TP Speed

JOURNAL OF COMPUTATIONAL BIOLOGY | MARY ANN LIEBERT, INC | Published : 2005

Abstract

Many short DNA motifs, such as transcription factor binding sites (TFBS) and splice sites, exhibit strong local as well as nonlocal dependence. We introduce permuted variable length Markov models (PVLMM) which could capture the potentially important dependencies among positions and apply them to the problem of detecting splice and TFB sites. They have been satisfactory from the viewpoint of prediction performance and also give ready biological interpretations of the sequence dependence observed. The issue of model selection is also studied.

University of Melbourne Researchers