A single-sample method for normalizing and combining full-resolution copy numbers from multiple platforms, labs and analysis methods
Henrik Bengtsson, Amrita Ray, Paul Spellman, Terence P Speed
BIOINFORMATICS | OXFORD UNIV PRESS | Published : 2009
MOTIVATION: The rapid expansion of whole-genome copy number (CN) studies brings a demand for increased precision and resolution of CN estimates. Recent studies have obtained CN estimates from more than one platform for the same set of samples, and it is natural to want to combine the different estimates in order to meet this demand. Estimates from different platforms show different degrees of attenuation of the true CN changes. Similar differences can be observed in CNs from the same platform run in different labs, or in the same lab, with different analytical methods. This is the reason why it is not straightforward to combine CN estimates from different sources (platforms, labs and analysi..View full abstract
Awarded by NCI
Awarded by NATIONAL CANCER INSTITUTE
Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
NCI grant U24 CA126551.