Journal article

Cell type- and estrogen receptor-subtype specific regulation of selective estrogen receptor modulator regulatory elements

Lonnele J Ball, Nitzan Levy, Xiaoyue Zhao, Chandi Griffin, Mary Tagliaferri, Isaac Cohen, William A Ricke, Terence P Speed, Gary L Firestone, Dale C Leitman

MOLECULAR AND CELLULAR ENDOCRINOLOGY | ELSEVIER IRELAND LTD | Published : 2009

Abstract

Selective estrogen receptor modulators (SERMs), such as tamoxifen and raloxifene can act as estrogen receptor (ER) antagonists or agonists depending on the cell type. The antagonistic action of tamoxifen has been invaluable for treating breast cancer, whereas the agonist activity of SERMs also has important clinical applications as demonstrated by the use of raloxifene for osteoporosis. Whereas the mechanism whereby SERMs function as antagonists has been studied extensively very little is known about how SERMs produce agonist effects in different tissues with the two ER types; ERalpha and ERbeta. We examined the regulation of 32 SERM-responsive regions with ERalpha and ERbeta in transiently ..

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University of Melbourne Researchers