Journal article
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
L Chin, M Meyerson, K Aldape, D Bigner, T Mikkelsen, S VandenBerg, A Kahn, R Penny, ML Ferguson, DS Gerhard, G Getz, C Brennan, BS Taylor, W Winckler, P Park, M Ladanyi, KA Hoadley, RGW Verhaak, DN Hayes, Paul T Spellman Show all
NATURE | NATURE PUBLISHING GROUP | Published : 2008
DOI: 10.1038/nature07385
Abstract
Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensional analysis of these molecular characteristics in human cancer and to provide the data rapidly to the research community. Here we report the interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas--the most common type of adult brain cancer--and nucleotide sequence aberrations in 91 of the 206 glioblastomas. This analysis provides new insights into the roles of ERBB2, NF1 a..
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Awarded by United States National Institutes of Health
Awarded by NATIONAL CANCER INSTITUTE
Awarded by NATIONAL HUMAN GENOME RESEARCH INSTITUTE
Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
Funding Acknowledgements
We thank the members of TCGA's External Scientific Committee, the Glioblastoma Disease Working Group (http:// cancergenome.nih.gov/components) and D. N. Louis for discussions; A. Mirick, J. Melone and C. Collins for administrative coordination of TCGA activities; and L. Gaffney for graphic art. This work was supported by the following grants from the United States National Institutes of Health: U54HG003067, U54HG003079, U54HG003273, U24CA126543, U24CA126544, U24CA126546, U24CA126551, U24CA126554, U24CA126561 and U24CA126563.