Journal article

Relative efficiencies of the Chi-square recombination models for gene mapping with human pedigree data

S Lin, TP Speed

ANNALS OF HUMAN GENETICS | CAMBRIDGE UNIV PRESS | Published : 1999

Abstract

In the paper by Goldstein et al. (Genomics, 1995), the authors carried out a simulation study to investigate the relative efficiencies of a no interference linkage analysis to an analysis with certain models that allow for interference. They showed that, for completely informative and independent recombination data, the analysis with the no interference model was inefficient, in the present of interference. In practice, the assumption of completely informative markers is unrealistic with data from human pedigrees. We report the results of a study investigating whether this conclusion still holds for gametes arising within pedigrees. We consider the same two mapping problems as Goldstein et a..

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University of Melbourne Researchers